Article

Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors

2022-07-07

Abstract excerpt

Botulinum neurotoxin A1 (BoNT/A1) is the most potent serotype in humans with the highest clinical duration. BoNT/A1 interacts with synaptic vesicle glycoprotein 2 (SV2) and gangliosides to be taken up by neurons. In this study, we present three molecular dynamics simulations in which BoNT/A1 is in complex with singly or doubly glycosylated SV2C or singly glycosylated SV2A, in a ganglioside rich (lipid raft) contex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2e60d08-8b86-58ab-a785-83cbe1316eb9
DOI: 10.1101/2022.07.06.498993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptorsDOI 10.1101/2022.07.06.498993Read

A Comprehensive Structural Analysis of Clostridium botulinum Neurotoxin A Cell-Binding Domain from Different SubtypesSemantic proximity Read

Molecular dynamics simulations of wild type and mutants of botulinum neurotoxin A complexed with synaptic vesicle protein 2C.Semantic proximity Read

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.Semantic proximity Read

Entry of Botulinum Neurotoxin Subtypes A1 and A2 into NeuronsSemantic proximity Read

Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.Semantic proximity Read

Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions.Semantic proximity Read

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum NeurotoxinsSemantic proximity Read

Molecular dynamic simulation reveals damaging impact of RAC1 F28L mutation in the switch I region.Semantic proximity Read

Botulinum Toxin: A Comprehensive Review of Its Molecular Architecture and Mechanistic ActionSemantic proximity Read

Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells.Semantic proximity Read

Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human Na <sub>V</sub> 1.7 ChannelSemantic proximity Read

Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 Å Resolution: Repercussions for VAMP-2 Substrate Specificity<sup>,</sup>Semantic proximity Read