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Article

Gangliosides as high affinity receptors for tetanus neurotoxin.

The Journal of biological chemistry - 25 Sept 2009

Chen Chen, Fu Zhuji, Kim Jung-Ja P, Barbieri Joseph T, Baldwin Michael R

Abstract excerpt

Tetanus neurotoxin (TeNT) is an exotoxin produced by Clostridium tetani that causes paralytic death to hundreds of thousands of humans annually. TeNT cleaves vesicle-associated membrane protein-2, which inhibits neurotransmitter release in the central nervous system to elicit spastic paralysis, but the molecular basis for TeNT entry into neurons remains unclear. TeNT is a approximately 150-kDa protein that has AB...

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Identifiers

PMID: 19602728
DOI: 10.1074/jbc.M109.027391
PMCID: PMC2785345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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