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Article

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.

Circulation research - 31 Jul 2015

Song Moshi, Gong Guohua, Burelle Yan, Gustafsson Åsa B, Kitsis Richard N, Matkovich Scot J, Dorn Gerald W

Abstract excerpt

RATIONALE: The role of Parkin in hearts is unclear. Germ-line Parkin knockout mice have normal hearts, but Parkin is protective in cardiac ischemia. Parkin-mediated mitophagy is reportedly either irrelevant, or a major factor, in the lethal cardiomyopathy evoked by cardiac myocyte-specific interruption of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission. OBJECTIVE: To understand the role of...

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Source

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Identifiers

PMID: 26038571
DOI: 10.1161/CIRCRESAHA.117.306859
PMCID: PMC4522211

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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