The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant.

doi:10.1074/jbc.273.36.23055

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Article

The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant.

The Journal of biological chemistry - 4 Sept 1998

Dierks E A, Zhang Z, Johnson E F, de Montellano P R

Abstract excerpt

CYP4A11, the principal known human fatty acid omega-hydroxylase, has been expressed as a polyhistidine-tagged protein and purified to homogeneity. Based on an alignment with P450BM-3, the CYP4A11 L131F mutant has been constructed and similarly expressed. The two proteins are spectroscopically ind...

Topics

Amino Acid Sequence
Bacterial Proteins
Binding Sites
Cytochrome P-450 CYP4A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Fatty Acids, Omega-3
Humans
Imidazoles
Imines
Mixed Function Oxygenases
Models, Molecular
Molecular Sequence Data
Mutation
NADPH-Ferrihemoprotein Reductase
Recombinant Proteins
Sequence Homology, Amino Acid
Stereoisomerism

Source

Open in PubMed

Identifiers

PMID: 9722531
DOI: 10.1074/jbc.273.36.23055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9722531-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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