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Article

Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice.

Oncotarget - 15 Nov 2016

Granados-Jaén Alba, Angulo-Ibáñez Maria, Rovira-Clavé Xavier, Gamez Celina Paola Vasquez, Soriano Francesc X, Reina Manuel, Espel Enric

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) is a cell cycle checkpoint kinase that upon activation by DNA damage leads to cell cycle arrest and DNA repair or apoptosis. The absence of Atm or the occurrence of loss-of-function mutations in Atm predisposes to tumorigenesis. MAPK7 has been implicated in numerous types of cancer with pro-survival and pro-growth roles in tumor cells, but its functional relation with tumor...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27793024
DOI: 10.18632/oncotarget.12908
PMCID: PMC5342677

Genes

MAPK7
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice.PMID 27793024Read ↗

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.Semantic proximity Read ↗

Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.Semantic proximity Read ↗

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