Article
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 1996
Elson A, Wang Y, Daugherty C J, Morton C C, Zhou F, Campos-Torres J, Leder P
Abstract excerpt
We have generated a mouse model for ataxia-telangiectasia by using gene targeting to generate mice that do not express the Atm protein. Atm-deficient mice are retarded in growth, do not produce mature sperm, and exhibit severe defects in T cell maturation while going on to develop thymomas. Atm-d...
Topics
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Cells, Cultured
- Chimera
- Crosses, Genetic
- DNA-Binding Proteins
- Embryo, Mammalian
- Exons
- Female
- Fibroblasts
- Genetic Carrier Screening
- Genotype
- Homozygote
- Humans
- Karyotyping
- Leucine Zippers