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Article

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 1996

Elson A, Wang Y, Daugherty C J, Morton C C, Zhou F, Campos-Torres J, Leder P

Abstract excerpt

We have generated a mouse model for ataxia-telangiectasia by using gene targeting to generate mice that do not express the Atm protein. Atm-deficient mice are retarded in growth, do not produce mature sperm, and exhibit severe defects in T cell maturation while going on to develop thymomas. Atm-deficient fibroblasts grow poorly in culture and display a high level of double-stranded chromosome breaks....

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Identifiers

PMID: 8917548
DOI: 10.1073/pnas.93.23.13084
PMCID: PMC24050

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.PMID 8917548Read ↗

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Pathogenesis of ataxia-telangiectasia: the next generation of ATM functionsSemantic proximity Read ↗

Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasiaSemantic proximity Read ↗

Mitochondrial dysfunction in ataxia-telangiectasiaSemantic proximity Read ↗

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