Article
Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation.
British journal of clinical pharmacology - 1 Apr 2017
Vinnard Christopher, Ravimohan Shruthi, Tamuhla Neo, Ivaturi Vijay, Pasipanodya Jotam, Srivastava Shashikant, Modongo Chawangwa, Zetola Nicola M, Weissman Drew, Gumbo Tawanda, Bisson Gregory P
Abstract excerpt
AIMS: Immune activation, which is characteristic of both tuberculosis (TB) and human immunodeficiency virus (HIV) infection, is associated with impaired drug metabolism. We tested the hypothesis that elevated levels of systemic immune activation among adults with HIV/TB initiating antiretroviral therapy (ART) would be associated with impaired clearance of isoniazid. METHODS: We conducted a prospective...
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