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Article

NAT2 Polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living With HIV: Insights From a Pharmacogenetic-Pharmacokinetic Cohort Study.

The Journal of infectious diseases - 18 Feb 2026

Hiranburana Napon, Sophonphan Jiratchaya, Kerr Stephen J, Ubolyam Sasiwimol, Usawakidwiree Warat, Torvorapanit Pattama, Suwanpimolkul Gompol, Phaisal Weeraya, Chariyavilaskul Pajaree, Cho Yong-Soon, Shin Jae-Gook, Mahasirimongkol Surakameth, Avihingsanon Anchalee

Abstract excerpt

BACKGROUND: The N-Acetyltransferase (NAT2) slow acetylator phenotype has been associated with a higher risk of isoniazid (INH)-induced hepatotoxicity. We investigated the association between NAT2 genotypes with inferred acetylator status, hepatotoxicity, and INH pharmacokinetics in Thai people living with HIV (PLWH) receiving INH-based Tuberculosis (TB) preventive or treatment regimens. METHODS: In this...

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PMID: 41037485
DOI: 10.1093/infdis/jiaf511

Genes

NAT2

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NAT2 Polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living With HIV: Insights From a Pharmacogenetic-Pharmacokinetic Cohort Study.PMID 41037485Read ↗

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