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Article

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype.

PloS one - 1 Jan 2016

Cooper James Ross, Abdullatif Muhammad Bilal, Burnett Edward C, Kempsell Karen E, Conforti Franco, Tolley Howard, Collins Jane E, Davies Donna E

Abstract excerpt

Pulmonary research requires models that represent the physiology of alveolar epithelium but concerns with reproducibility, consistency and the technical and ethical challenges of using primary or stem cells has resulted in widespread use of continuous cancer or other immortalized cell lines. The A549 'alveolar' cell line has been available for over four decades but there is an inconsistent view as to its...

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PMID: 27792742
DOI: 10.1371/journal.pone.0164438
PMCID: PMC5085087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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