Article
Breaking the in vitro alveolar type II cell proliferation barrier while retaining ion transport properties.
American journal of respiratory cell and molecular biology - 1 Apr 2014
Bove Peter F, Dang Hong, Cheluvaraju Chaitra, Jones Lisa C, Liu Xuefeng, O'Neal Wanda K, Randell Scott H, Schlegel Richard, Boucher Richard C
Abstract excerpt
Alveolar type (AT)I and ATII cells are central to maintaining normal alveolar fluid homeostasis. When disrupted, they contribute to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome. Research on ATII cells has been limited by the inability to propagate primary cells in vitro to study their specific functional properties. Moreover, primary ATII cells in vitro quickly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.