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Article

Assessment of cell line models of primary human cells by Raman spectral phenotyping.

Biophysical journal - 21 Apr 2010

Swain Robin J, Kemp Sarah J, Goldstraw Peter, Tetley Teresa D, Stevens Molly M

Abstract excerpt

Researchers have previously questioned the suitability of cell lines as models for primary cells. In this study, we used Raman microspectroscopy to characterize live A549 cells from a unique molecular biochemical perspective to shed light on their suitability as a model for primary human pulmonary alveolar type II (ATII) cells. We also investigated a recently developed transduced type I (TT1) cell line as a model...

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Identifiers

PMID: 20409492
DOI: 10.1016/j.bpj.2009.12.4289
PMCID: PMC2856139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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