Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

26 Oct 2016

Abstract excerpt

STUDY DESIGN: Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE: This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potential mechanism in human nucleus pulposus cells. SUMMARY OF BACKGROUND DATA: Silent mating type information regulator 2 homolog 1 (Sirt1) has draw immense attention...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical and Thoracic Myelopathy
Share to Spine and Intervertebral Disc Pathology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27792110
DOI: 10.1097/brs.0000000000001954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc DegenerationPMID 27792110Read ↗

SIRT1 Plays a Protective Role in Intervertebral Disc Degeneration in a Puncture-induced Rodent ModelSemantic proximity Read ↗

SIRT1 Inhibits the Catabolic Effect of IL-1βThrough TLR2/SIRT1/NF-κB Pathway in HumanDegenerative Nucleus Pulposus CellsSemantic proximity Read ↗

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degenerationSemantic proximity Read ↗

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cellsSemantic proximity Read ↗

SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagySemantic proximity Read ↗

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degenerationSemantic proximity Read ↗

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathwaySemantic proximity Read ↗

Retinoic acid inhibits the pyroptosis of degenerated nucleus pulposus cells by activating Sirt1-SOD2 signalingSemantic proximity Read ↗

Hypoxia-inducible Factor-1α protects against Intervertebral Disc Degeneration through Antagonizing Mitochondrial Oxidative Stress.Semantic proximity Read ↗

Knockout of miR-17-92 Cluster Protect Against Intervertebral Disc Degeneration by Inhibiting Apoptosis of Nucleus Pulposus Cells in Mice via the Activation of PI3K/Akt PathwaySemantic proximity Read ↗

Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axisSemantic proximity Read ↗

SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.