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Article

SIRT1 Plays a Protective Role in Intervertebral Disc Degeneration in a Puncture-induced Rodent Model

3 Feb 2015

Abstract excerpt

STUDY DESIGN: Experimental animal study of treatment of intervertebral disc (IVD) degeneration. OBJECTIVE: This report aims to evaluate the in vivo effects of SIRT1 on IVD biology and to explore its potential mechanism. SUMMARY OF BACKGROUND DATA: Silent mating type information regulator 2 homolog 1 (SIRT1) has attracted immense attention because of its functions in a variety of aging-related diseases. Despite...

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PMID: 25646749
DOI: 10.1097/brs.0000000000000817

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