Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway

4 Mar 2016

Abstract excerpt

Cartilage end plates (CEP) degeneration plays an integral role in intervertebral disc (IVD) degeneration resulting from nutrient diffusion disorders. Although cell senescence resulting from oxidative stress is known to contribute to degeneration, no studies concerning the role of senescence in CEP degeneration have been conducted. SIRT1 is a longevity gene that plays a pivotal role in many cellular functions,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Healthcare and Venom Research
Share to Sirtuins and Resveratrol in Medicine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26940203
DOI: 10.1038/srep22628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathwayPMID 26940203Read ↗

Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degenerationSemantic proximity Read ↗

[Research progress of cellular senescence and senescent secretary phenotype in intervertebral disc degeneration].Semantic proximity Read ↗

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironmentSemantic proximity Read ↗

Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degenerationSemantic proximity Read ↗

Cellular senescence and other age-related mechanisms in skeletal diseasesSemantic proximity Read ↗

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc DegenerationSemantic proximity Read ↗

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degenerationSemantic proximity Read ↗

Emerging role and therapeutic implications of p53 in intervertebral disc degenerationSemantic proximity Read ↗

Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc DegenerationSemantic proximity Read ↗

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degenerationSemantic proximity Read ↗

Cellular senescence in skeletal diseases: A bibliometric analysis from 2007 to 2024Semantic proximity Read ↗

Intervertebral disc cell fate during aging and degeneration: apoptosis, senescence, and autophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.