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SIRT1 Inhibits the Catabolic Effect of IL-1βThrough TLR2/SIRT1/NF-κB Pathway in HumanDegenerative Nucleus Pulposus Cells

14 Jan 2016

Abstract excerpt

BACKGROUND: Low back pain (LBP), one of the most prominent problems worldwide, lacks effective disease-modifying medical therapy. Intervertebral disc degeneration (IVDD) is a major cause of LBP, and proinflammatory cytokines are the key factors involved in the development of IVDD-induced back pain. Sirtuin 1 (SIRT1) is implicated in the molecular control of aging and immune responses in various diseases; however,...

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PMID: 26752489
DOI: 10.36076/ppj/2016.19.e215

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