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Article

Vertebrate isoforms of actin capping protein beta have distinct functions In vivo.

The Journal of cell biology - 13 Dec 1999

Hart M C, Cooper J A

Abstract excerpt

Actin capping protein (CP) binds barbed ends of actin filaments to regulate actin assembly. CP is an alpha/beta heterodimer. Vertebrates have conserved isoforms of each subunit. Muscle cells contain two beta isoforms. beta1 is at the Z-line; beta2 is at the intercalated disc and cell periphery in general. To investigate the functions of the isoforms, we replaced one isoform with another using expression in hearts...

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Identifiers

PMID: 10601341
DOI: 10.1083/jcb.147.6.1287
PMCID: PMC2168092

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