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Article

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.

Kidney international - 1 Feb 2017

Nezu Masahiro, Souma Tomokazu, Yu Lei, Suzuki Takafumi, Saigusa Daisuke, Ito Sadayoshi, Suzuki Norio, Yamamoto Masayuki

Abstract excerpt

Acute kidney injury is a devastating disease with high morbidity in hospitalized patients and contributes to the pathogenesis of chronic kidney disease. An underlying mechanism of acute kidney injury involves ischemia-reperfusion injury which, in turn, induces oxidative stress and provokes organ damage. Nrf2 is a master transcription factor that regulates the cellular response to oxidative stress. Here, we...

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Identifiers

PMID: 27789056
DOI: 10.1016/j.kint.2016.08.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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