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Nuclear factor E2-related factor-2 (Nrf2) regulates renal tubulointerstitial fibrosis and Gasdermin D-driven pyroptosis induced by high glucose in HK-2 cells via Caspase-1

2022-11-07

Abstract excerpt

Previous studies have shown that tubulointerstitial fibrosis (TIF) and pyroptosis are crucial in high-glucose (HG)-induced renal tubular epithelial cell injury and thus contribute to the development of diabetic nephropathy (DN). Previous reports have shown that Nrf2 plays an important role in the occurrence of anti-inflammatory and anti-fibrotic effects, but it is unclear whether Nrf2 has a common point of action...

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Literature Corpus work: e83e0bae-e9c8-57c7-88d7-62c1084df870
DOI: 10.21203/rs.3.rs-2194013/v1

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