Article
CD70 limits atherosclerosis and promotes macrophage function.
Thrombosis and haemostasis - 5 Jan 2017
Winkels Holger, Meiler Svenja, Smeets Esther, Lievens Dirk, Engel David, Spitz Charlotte, Bürger Christina, Rinne Petteri, Beckers Linda, Dandl Angelika, Reim Sigrid, Ahmadsei Maiwand, Van den Bossche Jan, Holdt Lesca M, Megens Remco T A, Schmitt Martin, de Winther Menno, Biessen Eric A, Borst Jannie, Faussner Alexander, Weber Christian, Lutgens Esther, Gerdes Norbert
Abstract excerpt
The co-stimulatory molecule CD70 is expressed on activated immune cells and is known to modulate responses of T, B, and NK cells via its receptor CD27. Until now, there is only limited data describing the role of CD70 in atherosclerosis. We observed that ruptured human carotid atherosclerotic plaques displayed higher CD70 expression than stable carotid atherosclerotic plaques, and that CD70 expression in murine...
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