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Article

The multi-functionality of CD40L and its receptor CD40 in atherosclerosis

1 Jan 2009

Abstract excerpt

Disrupting the CD40-CD40L co-stimulatory pathway reduces atherosclerosis and induces a stable atherosclerotic plaque phenotype that is low in inflammation and high in fibrosis. Therefore, inhibition of the CD40-CD40L pathway is an attractive therapeutic target to reduce clinical complications of atherosclerosis. The CD40-CD40L dyad is known to interact with other co-stimulatory molecules, to activate...

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PMID: 19652870
DOI: 10.1160/th09-01-0029

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