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Article

A new humanized in vivo model of KIT D816V+ advanced systemic mastocytosis monitored using a secreted luciferase.

Oncotarget - 13 Dec 2016

Bibi Siham, Zhang Yanyan, Hugonin Caroline, Mangean Mallorie Depond, He Liang, Wedeh Ghaith, Launay Jean-Marie, Van Rijn Sjoerd, Würdinger Thomas, Louache Fawzia, Arock Michel

Abstract excerpt

Systemic mastocytosis are rare neoplasms characterized by accumulation of mast cells in at least one internal organ. The majority of systemic mastocytosis patients carry KIT D816V mutation, which activates constitutively the KIT receptor. Patient with advanced forms of systemic mastocytosis, such as aggressive systemic mastocytosis or mast cell leukemia, are poorly treated to date. Unfortunately, the lack of in...

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Identifiers

PMID: 27783996
DOI: 10.18632/oncotarget.12824
PMCID: PMC5347747

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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