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Article

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

28 Mar 2014

Abstract excerpt

In systemic mastocytosis (SM), clinical problems arise from factor-independent proliferation of mast cells (MCs) and the increased release of mediators by MCs, but no human cell line model for studying MC activation in the context of SM is available. We have created a stable stem cell factor (SCF) -dependent human MC line, ROSA(KIT WT), expressing a fully functional immunoglobulin E (IgE) receptor. Transfection...

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PMID: 24677542
DOI: 10.1182/blood-2013-10-534685

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