Article
Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice.
Haematologica - 1 Oct 2016
Ustun Celalettin, Arock Michel, Kluin-Nelemans Hanneke C, Reiter Andreas, Sperr Wolfgang R, George Tracy, Horny Hans-Peter, Hartmann Karin, Sotlar Karl, Damaj Gandhi, Hermine Olivier, Verstovsek Srdan, Metcalfe Dean D, Gotlib Jason, Akin Cem, Valent Peter
Abstract excerpt
Systemic mastocytosis is a heterogeneous disease characterized by the accumulation of neoplastic mast cells in the bone marrow and other organ organs/tissues. Mutations in KIT, most frequently KIT D816V, are detected in over 80% of all systemic mastocytosis patients. While most systemic mastocytosis patients suffer from an indolent disease variant, some present with more aggressive variants, collectively called...
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