Article
A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis.
British journal of haematology - 1 Oct 2014
Balci Tugce B, Prykhozhij Sergey V, Teh Evelyn M, Da'as Sahar I, McBride Eileen, Liwski Robert, Chute Ian C, Leger Daniel, Lewis Stephen M, Berman Jason N
Abstract excerpt
Systemic mastocytosis (SM) is a rare myeloproliferative disease without curative therapy. Despite clinical variability, the majority of patients harbour a KIT-D816V mutation, but efforts to inhibit mutant KIT with tyrosine kinase inhibitors have been unsatisfactory, indicating a need for new preclinical approaches to identify alternative targets and novel therapies in this disease. Murine models to date have been...
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