Article
Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V.
The American journal of pathology - 1 Dec 2009
Baumgartner Christian, Cerny-Reiterer Sabine, Sonneck Karoline, Mayerhofer Matthias, Gleixner Karoline V, Fritz Richard, Kerenyi Marc, Boudot Cedric, Gouilleux Fabrice, Kornfeld Jan-Wilhelm, Sillaber Christian, Moriggl Richard, Valent Peter
Abstract excerpt
Recent data suggest that the signal transducer and activator of transcription (STAT)5 contributes to differentiation and growth of mast cells. It has also been described that constitutively phosphorylated STAT5 (pSTAT5) plays a pro-oncogenic role in various myeloid neoplasms. We examined the expression of pSTAT5 in neoplastic mast cells in systemic mastocytosis and asked whether the disease-related oncoprotein...
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