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Article

KIT D816V Mast Cells Derived from Induced Pluripotent Stem Cells Recapitulate Systemic Mastocytosis Transcriptional Profile.

International journal of molecular sciences - 9 Mar 2023

de Toledo Marcelo A S, Fu Xuhuang, Maié Tiago, Buhl Eva M, Götz Katrin, Schmitz Susanne, Kaiser Anne, Boor Peter, Braunschweig Till, Chatain Nicolas, Costa Ivan G, Brümmendorf Tim H, Koschmieder Steffen, Zenke Martin

Abstract excerpt

Mast cells (MCs) represent a population of hematopoietic cells with a key role in innate and adaptive immunity and are well known for their detrimental role in allergic responses. Yet, MCs occur in low abundance, which hampers their detailed molecular analysis. Here, we capitalized on the potential of induced pluripotent stem (iPS) cells to give rise to all cells in the body and established a novel and robust...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36982353
DOI: 10.3390/ijms24065275
PMCID: PMC10049485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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