Article
High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status.
Cancer immunology, immunotherapy : CII - 1 Jan 2017
Veluchamy John P, Heeren A Marijne, Spanholtz Jan, van Eendenburg Jaap D H, Heideman Daniëlle A M, Kenter Gemma G, Verheul Henk M, van der Vliet Hans J, Jordanova Ekaterina S, de Gruijl Tanja D
Abstract excerpt
Down-regulation of HLA in tumor cells, low numbers and dysfunctionality of NK cells are commonly observed in patients with end-stage cervical cancer. Adoptive transfer of high numbers of cytotoxic NK cells might be a promising treatment approach in this setting. Here, we explored the cytotoxic efficacy on ten cervical cancer cell lines of activated allogeneic NK cells from two sources, i.e., peripheral blood...
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