Article
In Vitro Killing of Colorectal Carcinoma Cells by Autologous Activated NK Cells is Boosted by Anti-Epidermal Growth Factor Receptor-induced ADCC Regardless of RAS Mutation Status.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 May 2018
Turin Ilaria, Delfanti Sara, Ferulli Federica, Brugnatelli Silvia, Tanzi Matteo, Maestri Marcello, Cobianchi Lorenzo, Lisini Daniela, Luinetti Ombretta, Paulli Marco, Perotti Cesare, Todisco Elisabetta, Pedrazzoli Paolo, Montagna Daniela
Abstract excerpt
Treatment of advanced metastatic colorectal cancer (mCRC) patients is associated with a poor prognosis and significant morbidity. Moreover, targeted therapies such as anti-epidermal growth factor receptor (EGFR) have no effect in metastatic patients with tumors harboring a mutation in the RAS gene. The failure of conventional treatment to improve outcomes in mCRC patients has prompted the development of adoptive...
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