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Article

Metabolic characterization of a mouse deficient in all known leptin receptor isoforms.

Cellular and molecular neurobiology - 1 Jan 2010

Osborn Olivia, Sanchez-Alavez Manuel, Brownell Sara E, Ross Brendon, Klaus Joe, Dubins Jeffrey, Beutler Bruce, Conti Bruno, Bartfai Tamas

Abstract excerpt

We have characterized a newly generated mouse model of obesity, a mouse strain deficient in all five previously described leptin receptor isoforms. These transgenic mice, named the db (333)/db (333) mice, were identified from an ENU mutagenesis screen and carry a point mutation in the seventh exon of the db gene encoding the leptin receptor, resulting in a premature stop codon (Y(333)Stop) and gene product that...

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Identifiers

PMID: 19582570
DOI: 10.1007/s10571-009-9427-x
PMCID: PMC2813927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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