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Article

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease

26 Oct 2016

Abstract excerpt

BACKGROUND: The transcription factor GATA2 orchestrates the expression of many endothelial-specific genes, illustrating its crucial importance for endothelial cell function. The capacity of this transcription factor in orchestrating endothelial-important microRNAs (miRNAs/miR) is unknown. METHODS: Endothelial GATA2 was functionally analyzed in human endothelial cells in vitro. Endogenous short interfering...

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PMID: 27780851
DOI: 10.1161/circulationaha.116.022478

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