Article
Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2012
Chan Yuk Cheung, Roy Sashwati, Khanna Savita, Sen Chandan K
Abstract excerpt
OBJECTIVE: MicroRNAs (miRs) regulate angiogenesis by posttranscriptional silencing of target genes. The significance of angiostatic miR-200b in switching on skin wound angiogenesis was tested. METHODS AND RESULTS: Wounding caused imminent and transient downregulation of miR-200b in dermal wound-edge endothelial cells. Derailing this injury response by lentiviral delivery of miR-200b in vivo impaired wound...
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