Article

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through <i>miR-126</i>

2019-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves (LVs) and lymphovenous valves (LVVs), and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GATA2 is required for VEC maintenance and morphogenesis. GATA2 is also necessary for the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7ae13aa-1782-5aa2-8249-160bff4af23f
DOI: 10.1101/660068

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through <i>miR-126</i>DOI 10.1101/660068Read

GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.Semantic proximity Read

Hdac3 regulates lymphovenous and lymphatic valve formationSemantic proximity Read

GATA2 is required for lymphatic vessel valve development and maintenance.Semantic proximity Read

Lymphatic vessel development: fluid flow and valve-forming cells.Semantic proximity Read

A GATA2-PROX1-FOXC2 regulatory axis integrates shear stress signaling with lymphatic vascular developmentSemantic proximity Read

Tie1 is required for lymphatic valve and collecting vessel developmentSemantic proximity Read

VE-Cadherin Is Required for Lymphatic Valve Formation and MaintenanceSemantic proximity Read

CXCL12/CXCR4 Governs Lymphatic Valve Formation Through Flow Dependent AKT/FOXO1/FOXC2 ActivationSemantic proximity Read

MicroRNA-Based Therapy of GATA2-Deficient Vascular DiseaseSemantic proximity Read

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.Semantic proximity Read

Endothelial Nitric Oxide Synthase Regulates Lymphatic Valve Specification By Controlling β - catenin Signaling During EmbryogenesisSemantic proximity Read

Lymph flow regulates collecting lymphatic vessel maturation in vivoSemantic proximity Read