Article
GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.
Development (Cambridge, England) - 5 Nov 2019
Mahamud Md Riaj, Geng Xin, Ho Yen-Chun, Cha Boksik, Kim Yuenhee, Ma Jing, Chen Lijuan, Myers Greggory, Camper Sally, Mustacich Debbie, Witte Marlys, Choi Dongwon, Hong Young-Kwon, Chen Hong, Varshney Gaurav, Engel James Douglas, Wang Shusheng, Kim Tae-Hoon, Lim Kim-Chew, Srinivasan R Sathish
Abstract excerpt
Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves and lymphovenous valves, and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GATA2 is required for VEC maintenance and morphogenesis. GATA2 is also necessary for the expression of the cell...
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