Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2017

Hahn David, Emoto Chie, Vinks Alexander A, Fukuda Tsuyoshi

Abstract excerpt

Organic cation transporter 1 (OCT1) plays an important role in the disposition of clinically important drugs, and the capacity of OCT1 activity is presumed to be proportional to the protein expression level in organ tissues. Knowledge of OCT1 protein expression in children, especially neonates and small infants, is currently very limited. Here, we report on the characterization of OCT1 protein expression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Infant

Share to Infant, Newborn

Share to Octamer Transcription Factor-1

Source

Open in PubMed Open full text

Identifiers

PMID: 27780835
DOI: 10.1124/dmd.116.072256
PMCID: PMC6047210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.PMID 27780835Read ↗

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.Semantic proximity Read ↗

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infantsSemantic proximity Read ↗

RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver DevelopmentSemantic proximity Read ↗

The organic anion transporter family: from physiology to ontogeny and the clinicSemantic proximity Read ↗

The human organic cation transporter OCT1 and its role as a target for drug responsesSemantic proximity Read ↗

Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and ResponseSemantic proximity Read ↗

Developmental expression of drug metabolizing enzymes: impact on disposition in neonates and young children.Semantic proximity Read ↗

Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.Semantic proximity Read ↗

Developmental regulation of kidney and liver solute carrier and ATP-binding cassette drug transporters and drug metabolizing enzymes: the role of remote organ communicationSemantic proximity Read ↗

Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients.Semantic proximity Read ↗

Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation.Semantic proximity Read ↗

Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of LifeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.