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Article

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics.

Clinical pharmacology and therapeutics - 1 Oct 2016

Prasad B, Gaedigk A, Vrana M, Gaedigk R, Leeder J S, Salphati L, Chu X, Xiao G, Hop Ceca, Evers R, Gan L, Unadkat J D

Abstract excerpt

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric (n = 69) and adult (n = 41) livers was quantified by liquid chromatography / tandem mass spectroscopy (LC-MS/MS). Transporter protein expression of OCT1, OATP1B3, P-gp, and MRP3 was age-dependent. Particularly, significant differences were observed in transporter expression (P < 0.05) between the following age groups:...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver-Specific Organic Anion Transporter 1

Share to Multidrug Resistance-Associated Protein 2

Share to Multidrug Resistance-Associated Proteins

Share to Organic Anion Transporters, Sodium-Independent

Share to Organic Cation Transporter 1

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

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PMID: 27301780
DOI: 10.1002/cpt.409
PMCID: PMC5017908

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