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RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver Development

27 Mar 2012

Abstract excerpt

During development, the maturation of liver transporters is essential for chemical elimination in newborns and children. One cannot compare the real abundance of transcripts by conventional messenger RNA (mRNA) profiling methods; in comparison, RNA-Seq provides a "true quantification" of transcript counts and an unbiased detection of novel transcripts. The purpose of this study was to compare the mRNA abundance...

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Drug Transport and Resistance Mechanisms
Liver Disease Diagnosis and Treatment
Pediatric Hepatobiliary Diseases and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22454430
DOI: 10.1093/toxsci/kfs107

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