Article
Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains.
Infection and immunity - 1 Jan 2001
Gingles N A, Alexander J E, Kadioglu A, Andrew P W, Kerr A, Mitchell T J, Hopes E, Denny P, Brown S, Jones H B, Little S, Booth G C, McPheat W L
Abstract excerpt
From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood...
Topics
- Animals
- Bacteremia
- Genetic Predisposition to Disease
- H-2 Antigens
- Lung
- Mice
- Mice, Inbred Strains
- Neutrophils
- Pneumococcal Infections
- Species Specificity