Article
Association of Variants in IL-1RN (rs2234663) and IL-1β (rs1143627, rs16944) and Interleukin-1β Levels with Colorectal Cancer: Experimental Study and In Silico Analysis.
Genes - 27 Nov 2024
Gallegos-Arreola Martha Patricia, Garibaldi-Ríos Asbiel Felipe, Gutiérrez-Hurtado Itzae Adonaí, Zúñiga-González Guillermo Moisés, Figuera Luis E, Gómez-Meda Belinda Claudia, Puebla-Pérez Ana María, García-Ortiz José Elías, Delgado-Saucedo Jorge I, Castro-García Paola Beatriz, Rentería-Ramírez María de Jesús, Torres-Mendoza Blanca Miriam
Abstract excerpt
BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) is a multifactorial disease where the inflammatory state is crucial. This study analyzes the association of the IL-1RN (rs2234663) and IL-1β (rs1143627, rs16944) variants and IL-1β levels with CRC. METHODS: This study included 230 CRC patients and 256 controls. Genotypes were determined by PCR and plasma IL-1β levels by ELISA. RegulomeDB analyzed the variants'...
Read the complete abstract on PubMed