Article
Single hemagglutinin mutations that alter both antigenicity and receptor binding avidity influence influenza virus antigenic clustering.
Journal of virology - 1 Sept 2013
Li Yang, Bostick David L, Sullivan Colleen B, Myers Jaclyn L, Griesemer Sara B, Stgeorge Kirsten, Plotkin Joshua B, Hensley Scott E
Abstract excerpt
The hemagglutination inhibition (HAI) assay is the primary measurement used for identifying antigenically novel influenza virus strains. HAI assays measure the amount of reference sera required to prevent virus binding to red blood cells. Receptor binding avidities of viral strains are not usually taken into account when interpreting these assays. Here, we created antigenic maps of human H3N2 viruses that...
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