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Article

Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes.

Respiratory research - 21 Oct 2016

Hodge Greg, Roscioli Eugene, Jersmann Hubertus, Tran Hai B, Holmes Mark, Reynolds Paul N, Hodge Sandra

Abstract excerpt

BACKGROUND: Corticosteroid resistance is a major barrier to effective treatment of COPD. We have shown that the resistance is associated with decreased expression of glucocorticoid receptor (GCR) by senescent CD28nullCD8+ pro-inflammatory lymphocytes in peripheral blood of COPD patients. GCR must be bound to molecular chaperones heat shock proteins (Hsp) 70 and Hsp90 to acquire a high-affinity steroid binding...

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Share to Adrenal Cortex Hormones
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Glucocorticoid

Source

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Identifiers

PMID: 27769261
DOI: 10.1186/s12931-016-0450-4
PMCID: PMC5075183

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