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Article

Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes.

Respiratory research - 24 Oct 2015

Hodge Greg, Jersmann Hubertus, Tran Hai B, Roscioli Eugene, Holmes Mark, Reynolds Paul N, Hodge Sandra

Abstract excerpt

BACKGROUND: Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that upregulate and down-regulate pro-inflammatory gene transcription respectively. HDAC2 is required by corticosteroids to switch off activated inflammatory genes and is reduced in lung macrophages in COPD. We have shown that COPD patients have increased steroid resistant CD28null (senescent) pro-inflammatory T and NKT-like...

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Identifiers

PMID: 26498345
DOI: 10.1186/s12931-015-0287-2
PMCID: PMC4619495

Genes

HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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