Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2013

Bae Jooeun, Munshi Aditya, Li Cheng, Samur Mehmet, Prabhala Rao, Mitsiades Constantine, Anderson Kenneth C, Munshi Nikhil C

Abstract excerpt

The 90-kDa heat shock protein (Hsp90) has become an important therapeutic target with ongoing evaluation in a number of malignancies. Although Hsp90 inhibitors have a high therapeutic index with limited effects on normal cells, they have been described to inhibit dendritic cell function. However, its effect on human immune effector cells may have significant clinical implications, but remains unexplored. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzoquinones
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP90 Heat-Shock Proteins

Share to Lactams, Macrocyclic

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Share to Multiple Myeloma

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Natural Killer Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 23293352
DOI: 10.4049/jimmunol.1200593
PMCID: PMC3819808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.PMID 23293352Read ↗

Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell.Semantic proximity Read ↗

Heat shock protein 90Semantic proximity Read ↗

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune diseaseSemantic proximity Read ↗

HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative NeoplasmsSemantic proximity Read ↗

Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB.Semantic proximity Read ↗

Facets of heat shock protein 70 show immunotherapeutic potentialSemantic proximity Read ↗

Chaperoning the Cancer: The Proteostatic Functions of the Heat Shock Proteins in CancerSemantic proximity Read ↗

Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast CancerSemantic proximity Read ↗

Heat Shock Protein 90 and Heat Shock Protein 70 Are Components of Dengue Virus Receptor Complex in Human CellsSemantic proximity Read ↗

Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptorSemantic proximity Read ↗

The role of hsp90 in SLE.Semantic proximity Read ↗

HSP70 Multi-Functionality in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.