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Article

Down Regulation of T Cell Receptor Expression in COPD Pulmonary CD8 Cells

19 Aug 2013

Abstract excerpt

CD8 cells may contribute towards an autoimmune process in COPD. Down regulation of T cell receptor (TCR) signalling molecules occurs in autoimmune diseases with consequent T cell dysfunction. We hypothesise that TCR signalling is abnormal in COPD pulmonary CD8 cells. Micro-array gene expression analysis of blood and pulmonary COPD CD8 samples was performed and compared to pulmonary CD8 cells from smoker controls...

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PMID: 23977094
DOI: 10.1371/journal.pone.0071629

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