Alterations to the remote control of Shh gene expression cause congenital abnormalities.

Abstract excerpt

Multi-species conserved non-coding elements occur in the vertebrate genome and are clustered in the vicinity of developmentally regulated genes. Many are known to act as cis-regulators of transcription and may reside at long distances from the genes they regulate. However, the relationship of conserved sequence to encoded regulatory information and indeed, the mechanism by which these contribute to long-range...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Congenital Abnormalities
• Share to Conserved Sequence