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Article

Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018

Mouri Kousuke, Sagai Tomoko, Maeno Akiteru, Amano Takanori, Toyoda Atsushi, Shiroishi Toshihiko

Abstract excerpt

Acquisition of new cis-regulatory elements (CREs) can cause alteration of developmental gene regulation and may introduce morphological novelty in evolution. Although structural variation in the genome generated by chromosomal rearrangement is one possible source of new CREs, only a few examples are known, except for cases of retrotransposition. In this study, we show the acquisition of novel regulatory sequences...

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Share to Enhancer Elements, Genetic
Share to Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Inbred ICR

Share to Mice, Mutant Strains

Share to Mutagenesis, Insertional

Share to Syndactyly

Source

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Identifiers

PMID: 29255029
DOI: 10.1073/pnas.1713339115
PMCID: PMC5798340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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