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Article

Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV.

Journal of the American Chemical Society - 17 Aug 2011

Banerjee Surajit, Brown Kyle L, Egli Martin, Stone Michael P

Abstract excerpt

Aflatoxin B(1) (AFB(1)) is oxidized to an epoxide in vivo, which forms an N7-dG DNA adduct (AFB(1)-N7-dG). The AFB(1)-N7-dG can rearrange to a formamidopyrimidine (AFB(1)-FAPY) derivative. Both AFB(1)-N7-dG and the β-anomer of the AFB(1)-FAPY adduct yield G→T transversions in Escherichia coli, but the latter is more mutagenic. We show that the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) bypasses...

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Identifiers

PMID: 21790157
DOI: 10.1021/ja2015668
PMCID: PMC3154525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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