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Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase

22 May 2008

Abstract excerpt

As a widely used anticancer drug, cis-diamminedichloroplatinum(II) (cisplatin) reacts with adjacent purine bases in DNA to form predominantly cis-[Pt(NH(3))(2){d(GpG)-N7(1),-N7(2)}] intrastrand cross-links. Drug resistance, one of the major limitations of cisplatin therapy, is partially due to the inherent ability of human Y-family DNA polymerases to perform translesion synthesis in the presence of DNA-distorting...

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PMID: 18499711
DOI: 10.1093/nar/gkn309

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