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Article

1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Lalande Julie, Halley Hélène, Balayssac Stéphane, Gilard Véronique, Déjean Sébastien, Martino Robert, Francés Bernard, Lassalle Jean-Michel, Malet-Martino Myriam

Abstract excerpt

In the quest for biomarkers of onset and progression of Alzheimer's disease, a 1H NMR-based metabolomic study was performed on the simple single-transgenic Tg2576 mouse model. These mice develop a slow cognitive decline starting by 6 months and express amyloid plaques from 10 months of age. The metabolic profiles of extracts from five brain regions (frontal cortex, rhinal cortex, hippocampus, midbrain, and...

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PMID: 24145382
DOI: 10.3233/JAD-130023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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