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Article

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Cancer cell - 3 Feb 2009

Guertin David A, Stevens Deanna M, Saitoh Maki, Kinkel Stephanie, Crosby Katherine, Sheen Joon-Ho, Mullholland David J, Magnuson Mark A, Wu Hong, Sabatini David M

Abstract excerpt

mTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this function of mTORC2 is critical for cancer progression is unknown. Here, we show that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice. Furthermore, we find that Rictor is a haploinsufficient gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

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Source

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Identifiers

PMID: 19185849
DOI: 10.1016/j.ccr.2008.12.017
PMCID: PMC2701381

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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