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TLR9 activation suppresses inflammation in response to Helicobacter pylori infection

7 Oct 2016

Abstract excerpt

Helicobacter pylori ( H. pylori) induces chronic gastritis in humans, and infection can persist for decades. One H. pylori strain-specific constituent that augments disease risk is the cag pathogenicity island. The cag island encodes a type IV secretion system (T4SS) that translocates DNA into host cells. Toll-like receptor 9 (TLR9) is an innate immune receptor that detects hypo-methylated CpG DNA motifs. In this...

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PMID: 27758771
DOI: 10.1152/ajpgi.00175.2016

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